Jan 01, 2017 imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Your doctor will decide how much imipenemcilastatin you need. Imipenemcilastatin side effects, dosage, interactions. Imipenem is distributed into most body tissues and fluids including heart valve, bone, uterus, ovary, intestine, saliva, sputum, bile, as well as peritoneal, pleural, and wound fluids. Imipenem binds to the bacterial cell wall, resulting in cell death. This medicine will not work for colds, flu, or other virus infections. Imipenemresiststheactionsofmanyenzymesthatdegrademostotherpenicillinsandpenicillinlikeantiinfectives.
Imipenemcilastatin will be prepared and given to you by a doctor or another health care professional. Following intravenous infusion of imipenem and cilastatin at a combined concentration of 10 mgkg of body weight, drug levels in plasma were determined serially during off and onhemodialysis periods, which were 2 and 4 h, respectively. An equivalent amount of cilastatin is also present in the solution. Combination with cilastatin prevents renal inactivation of imipenem, resulting in high urinary concentrations. Consider other antibacterialdrugs to treat infections in patients whose seizures are wellcontrolled on valproic acid or divalproex sodium5. In vitro studies have demonstrated that imipenem has an extremely wide spectrum of antibacterial activity against gramnegative and grampositive aerobic and anaerobic bacteria, even against. Nov 09, 2018 imipenem is an antibiotic that fights bacteria. Imipenem and cilastatin may also be used for purposes not listed in this medication guide. For intravenous infusion dilute to a concentration of 5 mg as imipenemml in sodium chloride 0. Approximately 20% of imipenem and 40% of cilastatin are protein bound. A reduction in dose must be made for patients with creatinine clearance less than. In vitro studies have demonstrated that imipenem has an extremely wide spectrum of antibacterial activity against gramnegative and grampositive aerobic and anaerobic bacteria, even. Imipenem cilastatin will be prepared and given to you by a doctor or another health care professional. Imipenem and cilastatin combination is used to treat infections in many different parts of the body.
Imipenem with cilastatin drug bnf content published by. Primaxin imipenem and cilastatin for injection, for intravenous use. Cefepime versus imipenemcilastatin for treatment of nosoco. Addition of cilastatin prevents renal inactivation of imipenem, resulting in increased urinary concentration. No hay estudios adecuados y bien controlados en mujeres gestantes. Imipenemcilastatin injection primaxin side effects. Imipenem cilastatina hospira contiene dos medicamentos diferentes llamados imipenem y cilastatina.
Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. These doses should be used for patients with creatinine clearance of greater than or equal to 90mlmin. It is made from a combination of imipenem and cilastatin. Imipenem is the first available semisynthetic thienamycin and is administered intravenously in combination with cilastatin,1 a renal dipeptidase inhibitor that increases urinary excretion of active drug. Removal of imipenem and cilastatin by hemodialysis in. In the workplace, this material should be considered potentially.
Imipenem has a high degree of stability in the presence of betalactamases, including both penicillinases and cephalosporinases produced by gramnegative and grampositive bacteria. Imipenem and cilastatin for injection is a powder containing imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase i. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intraabdominal infections, and urinary tract infections. Imipenemcilastatin definition of imipenemcilastatin by. This medicine will not work for colds, flu, or other virus infections imipenem and cilastatin combination is used to treat infections in many different parts of the body. Adults the usual dose of imipenem cilastatin for adults is 500 mg500 mg every 6 hours or 1,000 mg1,000 mg every 6 or 8 hours. The dosage of imipenem and cilastatin for injection i. The antibacterial spectrum of imipenem exceeds any antibiotic investigated to date and includes grampositive, gramnegative, and anaerobic organisms. Jul 09, 2019 imipenem convulsiones pdf two elderly patients with a history of either cerebral vascular accident cva or head trauma and no evidence of renal disease developed seizures while. Tore midtvedt, in side effects of drugs annual, 2008. Mar 18, 2020 imipenem mas cilastatina pdf in vitro comparison of ertapenem, meropenem, and imipenem against isolates of cefozopran, meropenem or imipenemcilastatinas initial therapy for fn.
Oct 18, 2012 imipenem is the first available semisynthetic thienamycin and is administered intravenously in combination with cilastatin,1 a renal dipeptidase inhibitor that increases urinary excretion of active drug. Imipenemcilastatin by injection national library of. The removal of imipenem and cilastatin by hemodialysis was studied in 14 for imipenem and 6 for cilastatin subjects. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l, with sodium bicarbonate added as a buffer. Imipenemcilastatin is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine.
Adults the usual dose of imipenemcilastatin for adults is 500 mg500 mg every 6 hours or 1,000 mg1,000 mg every 6 or 8 hours. It is a broadspectrum antibacterial agent given by intravenous administration. At least one of the suspected causative pathogens from the specimen meets all of the following. Accidental release measures contain spill and collect, as appropriate. May 22, 2015 at least one of the suspected causative pathogens from the specimen meets all of the following. It works by killing bacteria or preventing their growth. How to use imipenemcilastatin suspension for reconstitution. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Dailymed imipenem and cilastatin imipenem and cilastatin. Before using imipenem with cilastatin, tell your doctor or pharmacist if you are allergic to either of its ingredients. Antiinfective pregnancy risk category c action acts against many grampositive and gramnegative organisms by binding to bacterial cell wall, causing cell death.
Concomitant use with primaxin is generally not recommended. In icu patients, the main current role for imipenem, meropenem and doripenem remains. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. For adult patients with normal renal function creatinine clearance of greater than or equal to 90 mlmin, the recommended dosage regimens are. Imipenem 500 mgcilastatin 500 mg is a white to light yellow powder for solution for infusion in a glass vial. Imipenemcilastatin an overview sciencedirect topics. It is a potent inhibitor of betalactamases from certain gramnegative bacteria that may be inherently resistant to many betalactam antibiotics e. Imipenem indicaciones, dosificacion, presentacion, efectos.
Imipenem with cilastatin drug bnfc content published. When imipenem and cilastatin is injected intravenously, it is usually infused injected slowly over a period of 20 minutes to 1 hour every 6 or 8 hours. Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously into a vein or intramuscularly into a muscle. Imipenem and cilastatin combination is used in the treatment of infections caused by bacteria.